Cre recombinase (Cre) is able to recombine specific sequences of DNA without the need for cofactors. The enzyme recognizes 34 base pair DNA sequences called loxP ("locus of …

As of 2019, the live colony of Stock No. 007001 has been backcrossed a total of at least 11 generations (the last seven backcross generations were onto C57BL/6J).

CreERT由三个关键字Cre、ER、T组合而成，分别对应于 CreERT 系统中的三个关键物质： Cre 重组酶、雌激素受体（ER，estrogen receptor）和药物他莫昔芬（T，Tamoxifen）。 …

008463 B6.129-<i>Gt (ROSA)26Sor^{tm1 (cre/ERT2)Tyj}</i>/J This strain enables temporal control of floxed gene expression by tamoxifen induction <i>in vivo</i>.

The second generation of inducible Cre-ERT recombinase, hemizygous B6.129S-Tg (UBC-cre/ERT2)1Ejb/J (hereafter abbreviated as Cre-ERT2), a fusion of a mutated estrogen …

Sep 17, 2020 · In addition to establishing optimal dose and administration of TAM, our study reveals a disparate activity of Cre in different cell immune populations when using Cre/ER …

This chimeric protein, called Cre‐ERT, was further modified to increase its sensitivity by the insertion of three different mutations in the hER‐LBD sequence (namely G400V, M543A, and …

Recent development of the tamoxifen-inducible Cre-ER T2 offers both cell type-specific and temporal control of conditional gene inactivation.

016261 C57BL/6-Tg (Nes-cre/ERT2)KEisc/J <i>Nestin-Cre/ERT2</i> transgenic mice express tamoxifen-inducible Cre recombinase in adult and developing mouse brain, including neuronal …

We have developed a conditional and inducible DNA recombination system for cell populations defined by the simultaneous activity of two promoters. The ERT2 tamoxifen binding domain of …