Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. [5] The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family.

Mar 30, 2025 · CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression.

Our structure reveals an intricate network of interactions between CDK7 and its two binding partners MAT1 and Cyclin H, providing a structural basis for the mechanism of CDK7 activation and CAK activity regulation.

Cdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK-activating kinase (CAK) for at least one other essential CDK involved in transcription.

According to the median, Kaplan-Meier curve indicates a significantly worse DFS for patients with CDK7 high expression in NSCLC than for patients with CDK7 low expression in NSCLC (log-rank test p 0.022; Figure 5A). 5-year disease-free survival rates were 32% and 56% for high and low CDK7 expression, respectively.

Jun 8, 2023 · CDK7 acts as a central hub for the perturbed cyclin-dependent kinase-pRb-E2F pathway in MM cells. CDK7 inhibition impairs expression of key components of the MYC-dependent glycolytic cascade and aerobic glycolysis in MM cells.

The plot of the root -mean -square deviation (RMSD) of the receptor backbone vs simulation duration for a solvated CDK7 receptor complexes with DB07075, DB07163 and DB07025 during a 200 ns...

Jul 19, 2004 · As a first step toward understanding the recognition properties of CDK7, we report the crystal structure of CDK7 phosphorylated on Thr170 and in complex with ATP. The kinase is in an inactive conformation similar to that of inactive CDK2 …

CDK7 is both a CDK-activating kinase (CAK) and a component of the general transcription factor TFIIH. An intricate network of cyclin-dependent kinases (CDKs) is organized in a pathway to ensure that each cell accurately replicates its DNA and segregates it equally between the two daughter cells. [1] .

Feb 14, 2024 · In this review, we provide a comprehensive summary of the latest insights into CDK7 biology and recent advancements in CDK7 inhibitor development for breast cancer treatment.