Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes.

Mar 30, 2025 · CDH2 (Cadherin 2) is a Protein Coding gene. Diseases associated with CDH2 include Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome and Attention Deficit-Hyperactivity Disorder 8. Among its related pathways are Cell junction organization and Blood-Brain Barrier: Anatomy.

CDH2 belongs to the classic cadherin family of Ca2+-dependent cell adhesion molecules with a meticulously described dual role in cell adhesion and β-catenin signaling. During CNS development, CDH2 is involved in a wide range of processes including ...

In this review, we focus on the role of cadherin mediated signaling in development and stem cell differentiation, with emphasis on two well-known cadherins, cadherin-2 (CDH2) (N-cadherin) and cadherin-11 (CDH11) (OB-cadherin).

Jan 4, 2025 · Gene target information for CDH2 - cadherin 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Here we focus on the role of the cell adhesion molecule N-cadherin (CDH2) within the malignant BM microenvironment and associated signalling pathways that may bear promise as therapeutic targets.

Sep 23, 2022 · CDH2 belongs to the classic cadherin family of Ca²⁺-dependent cell adhesion molecules with a meticulously described dual role in cell adhesion and β-catenin signaling. During CNS development, CDH2 is involved in a wide range of processes including maintenance of neuroepithelial integrity, …

Oct 26, 2021 · Here we demonstrate familial ADHD caused by a missense mutation in CDH2, which encodes the adhesion protein N-cadherin, known to play a significant role in synaptogenesis; the mutation affects...

CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. Specific N-cadherin-dependent pathways drive human breast cancer dormancy in bone marrow.

The CDH2 gene encodes N (neuronal)-cadherin, which has an essential role in the early steps of brain morphogenesis (summary by Halperin et al., 2021).