Cadherin-1 is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail.

The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. This protein is found within the membrane that surrounds epithelial cells, which are the cells that line the surfaces and cavities of the body, such as the inside of the eyelids and mouth.

Jul 22, 2021 · Having a CDH1 mutation means that you are at high risk for developing a very aggressive form of stomach cancer called hereditary diffuse gastric cancer (HDGC). The CDH1 mutation also puts women at risk for a certain form of breast cancer called lobular breast cancer.

Effect of Family History on Estimated Lifetime Risk of Gastric Cancer. Table 1. Characteristics of Kindreds and Individuals With Germline CDH1 P/LP Variants. Table 2. Hazard Ratio and Cumulative Risk Estimates of Advanced Gastric and Breast Cancer for …

We review current perspectives in CDH1 genetics with molecular mechanisms and also discuss management strategies for this aggressive form of gastric cancer.

Among individuals with a CDH1 gene variant, the risk of gastric cancer was lower than previously described, while risk of breast cancer among female carriers was similar to previous estimates. Approximately 1% to 3% of gastric cancers and 5% of lobular breast cancers are hereditary.

Carrying a mutation in the CDH1 gene raises the risk of diffuse gastric cancer as much as 70% for men and 56% for women, compared to a <1% chance in people without a CDH1 mutation. What is the CDH1 gene and how does this gene play a role …

Jan 14, 2025 · Results: Two hundred and thirteen kindreds (extended families) with CDH1 P/LP variants, consisting of 7,232 individuals; 85% were White and 49% female. The average age at diagnosis of gastric cancer was 49 (interquartile range …

Mutations of CDH1, the gene encoding E-cadherin, are the most common germline mutations detected in gastric cancer and underlie hereditary diffuse gastric cancer (HDGC) syndrome. All reported HDGCs are the pure diffuse type by Lauren classification and are associated with dismal prognosis once the tumor invades the submucosa.

Raising awareness about pathogenic genetic mutations. focusing on cdh1 mutations and associated health conditions. The CDH1 gene makes epithelial cadherein protein. e-cadherein helps neighboring cells stick together to form tissues that line …