Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on …

Cluster of differentiation 86 (CD86), also known as B7-2, is a molecule expressed on antigen-presenting cells that provides the costimulatory signals required for T cell activation and …

Mar 28, 2025 · CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Plague and Cowpox . Among its related pathways are CD28 co-stimulation and …

CD86 refers to a 70-kDa glycoprotein consisting of 329 amino acids, a transmembrane region, and a longer cytoplasmic domain. It is expressed on various immune cells such as …

CD86 is expressed on antigen-presenting cells and serves as a ligand for two proteins on T cells, CD28 and CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). The binding of CD86 to …

Apr 7, 2023 · CD86 appears to participate in immune invasion in AML and is an important player in the tumor microenvironment in this malignancy. At the same time, the IRS score developed …

Aug 23, 2022 · Furthermore, we identified clinically relevant mutations that cause autoimmune disease, which selectively disrupted CD86 transendocytosis, by affecting either CTLA-4 …

Apr 3, 2025 · Of the above-described candidates, CD86 was most highly expressed on cHL cell lines with overall comparable expression to CD30 (supplemental Figure 1A). Comparison to …

Learn about the CD86 gene, its function as a costimulatory molecule in immune responses, its role in T cell activation and antigen presentation, and its implications for immunotherapy and …

Dendritic cells (DCs) require costimulatory molecules such as CD86 to efficiently activate T cells for the induction of adaptive immunity. DCs maintain minimal levels of CD86 expression at …