Sep 11, 2017 · NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection.

During persistent antigen stimulation, CD8 + T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors and infections. Here we demonstrate that the transcription factor NFAT controls the program of T cell exhaustion.

Feb 17, 2015 · During persistent antigen stimulation, CD8(+) T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors and infections. Here we demonstrate that the transcription factor NFAT controls the program of T …

Dec 12, 2024 · To examine factors downstream of TCR signaling, we focused on nuclear factor of activated T cells (NFAT), a transcription factor that orchestrates CD8 + T cell activation and exhaustion (31, 32).

Jurkat-Lucia™ NFAT Cells were specifically designed to assess activation of the NFAT (nuclear factor of activated T cells) transcription factor ipon stimulation with small molecules mimicking the TCR activation signal.

Jun 30, 2022 · Dapl1 controls activation of NFATc2, a transcription factor required for the effector function of CD8 + T cells. Although NFATc2 mediates induction of the immune checkpoint receptor Tim3,...

Sep 11, 2017 · Nfatc1 -/-, but not Nfatc2 -/-CD8 + T cells have an impaired metabolic switch to glycolysis, which can be restored by IL-2. Genome-wide ChIP-seq shows that NFATc1 binds many genes that control cytotoxic T lymphocyte activity.

CD8+ T cell differentiation orchestrated by transcription regulators is critical for balancing pathogen eradication and long-term immunity by effector and memory CTLs, respectively. The transcription factor Nuclear Factor of Activated T cells (NFAT) ...

Here we found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8 + T cells in the context of chronic infections and tumors but was selectively required in tumor-induced CD8 + T cell exhaustion.

Feb 17, 2015 · During persistent antigen stimulation, CD8+ T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors and infections. Here we demon-strate that the transcription …