Cytotoxic CD8+ T cells promote granzyme B-dependent adverse …
Mar 5, 2021 · Depletion of CD8 + T lymphocytes decreases apoptosis within the ischemic myocardium, hampers inflammatory response, limits myocardial injury and improves heart …
Granzyme B + CD8 + T cells with terminal differentiated effector ...
Jun 2, 2023 · Our study mapped peripheral immune cells of RRMS and SPMS patients and provided an evidence for the involvement of GzmB + CD8 + T EMRA cells in the progression …
Granzyme B in circulating CD8+ T cells as a biomarker of
Nov 9, 2022 · Our study support the involvement of GzmB-expressing CD8+ T cells in the inflammatory response in patients with NMOSD and provide a potential biomarker for disease …
Granzyme K + CD8 T cells form a core population in inflamed
Jun 15, 2022 · Using T cell receptor repertoire data, we found that CD8 GzmK + GzmB + T cells are clonally expanded in synovial tissues and maintain their granzyme expression and overall …
Targeting PD-1 and CD85j can restore intratumoral CD4+ GzmB
Several studies have reported that IL-15 increases GzmB and perforin expression in CD8 + T cells. 20 21 Moreover, IL-15 preferentially increases expansion and improves the effector …
Visualization of granzyme B-expressing CD8 T cells during primary …
Apr 14, 2015 · In this study we used CD8 T cells from OT1 mice and CD4 T cells from OT2 mice expressing a fluorescent chimeric granzyme (GZMB-Tom) protein to monitor the primary …
Single-cell atlas of healthy human blood unveils age-related loss …
Nov 13, 2023 · NKG2C + GZMB – XCL1 + defines a unique memory CD8 + T cell subset that decreases with age. HLA-DR + CD4 + memory T cells and GZMK + CD8 + T cells accumulate …
Granzyme B in aging and age-related pathologies - Cell Press
Aug 23, 2024 · In atherosclerosis, GzmB co-localizes to CD8 + T cells, CD68 + macrophages, and SMA + smooth muscle cells within human plaques. GzmB induces smooth muscle cell …
The NET-DNA-CCDC25 inhibitor di-Pal-MTO suppresses tumor
3 days ago · As expected, the proportion of DCs, CXCL9 expression in DCs, and the percentage of CD8 + T cells as well as GZMB + CD8 + T cells were significantly increased in the di-Pal …
Combination radiation and αPD-L1 enhance tumor control by
3 days ago · d Density plots showing expression levels of Tcf7, Ly6a, Tox, Klrk1, Ccrl2, and Gzmb in CD8+ Tcf7-expressing PD-1+ T cells from the TdLN, with color intensity representing scaled …