These results suggest that CCR4 (+)CD8 (+) T cells are in an immature memory T cell subset in the differentiation pathway of human CD8 (+) T cells and that they migrate to inflammatory …

From our previous data on psoriasis patients, CCR4 + memory T cells emerged as a putative recirculating population between skin and blood. Here we focused our attention on the …

Nov 13, 2023 · We observe age-related accumulation of T helper (Th)2-like CD4 + memory cells and CCR4+ CD8 + central memory T cells, the latter of which are enriched in type 2 immune …

Dec 14, 2021 · Comprehensive immune-monitoring reveals that the abundance of CCR4-expressing central memory CD8 + T cells that are known to play roles in the antitumor immune …

Feb 3, 2023 · In patients with psoriatic arthritis, scRNA-seq and TCR sequencing data showed clonal expansion of CCR4 + T CM cells in the circulation and further expansion in the synovial …

In this study, we explored the expression of CCR4 within the spectrum of CD8+ CTCLs and LPDs and its potential as a treatment target in these rare diseases.

Mar 4, 2009 · The CC chemokine receptor (CCR)4 is associated with trafficking of specialized cutaneous memory type 2 T h cells in the skin. However, a CD8 + T cell population expressing …

Mar 1, 2018 · Among αβ T cells, CCR8 was expressed by both the CD4 + and CD8 + subsets in the dermis and epidermis (Fig. 1D, 1E), with a greater percentage of CD4 + CCR8 + T cells in …

In summary, CCR4 and CCR5 were found to be strongly upregulated in CD8 T cells of patients with severe COVID-19 infection, mainly presenting with pulmonary failure.

As CCR4 expression was highly increased both in CD4 and CD8 T cells in our severely diseased patients, we hypothesize that in severe cases of COVID‐19, increased numbers of CCR4 …