CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.

Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...

Cytotoxic CD8 + T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8 + T cell metabolism is coupled to transcriptional, translational and epigenetic changes that …

4 days ago · CD8+ T cells that are repeatedly exposed to antigenic stimulation, such as in the context of progressing neoplasms and chronic viral infections, acquire a dysfunctional or hypofunctional state ...

Sep 15, 2020 · Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.

CD8 is a dimeric receptor that contains several domains: ectodomain, hinge, transmembrane, and cytoplasmic tail (7). CD8 primarily acts as a co-stimulator, and occasionally as a co-repressor, of immune responses (7, 8).

In this article we discuss how inflammatory cytokines and IL-2 bias the initial response towards short-lived effector generation and also highlight the potential counterbalancing role of IL-21.

Learn about cytotoxic T cells, also referred to as CD8+ T cells, including cell activation, differentiation, and function in adaptive immune response.

CD8 + T cells that are repeatedly exposed to antigenic stimulation, such as in the context of progressing neoplasms and chronic viral infections, acquire a dysfunctional or hypofunctional state that is generally known as exhaustion. There have been considerable efforts to develop therapeutic strategies that prevent exhaustion in these pathological scenarios, but there has …

As CD8 T cells underwent a second phase of stable interactions with DCs, helper CD4 T cells halted briefly before moving on to another DC, whereas regulatory T cells did not stop. This cellular choreography could facilitate CD8 T cells with high affinity for antigen to receive interleukin-2 signals from helper CD4 T cells to promote their ...