CD70 (C luster of D ifferentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is also known as a ligand for CD27. [1] In physiological condition the expression of CD70 on immune cells is transient and tightly controlled.

Mar 28, 2025 · CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Lymphoproliferative Syndrome 3 and Primary Immunodeficiency With Predisposition To Severe Viral Infection. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling.

Jul 14, 2020 · The expression of CD70 in expanded Tregs is associated with a profound loss of regulatory function and an unusual ability to provide CD70-directed co-stimulation to TCR-activated conventional...

Jan 6, 2022 · In this review on the CD70-CD27 axis, we focus on immunotherapeutic strategies aiming at eradicating the tumor cells by specifically targeting tumor-associated CD70 overexpression, thereby abrogating the immune suppressive effects driven by chronic stimulation of the CD70-CD27 axis.

In this review, we summarize the targetable expression patterns of CD70 in a wide range of malignancies and the promising mechanism of anti-CD70 therapy in stimulating the anti-tumor immune response. In addition, we will discuss clinical data and future combination strategies.

Feb 13, 2025 · CD70 has emerged as a promising target in acute myeloid leukemia (AML), and we have previously demonstrated the potency of an optimized CD70-targeted ligand-based chimeric antigen receptor (CAR). However, here, we identify in vivo CD70 antigen escape as a limitation of single-antigen targeting.

CD70 expression on ex vivo CD4 + T lymphocytes defines a pathogenic and proinflammatory subpopulation. In humans, CD70 is mainly induced after activation and predominantly expressed on antigen-presenting cells.

Oct 24, 2024 · Extensive research has demonstrated that dysregulation of costimulatory molecule expression plays a pivotal role in cancer biology. However, the impact of intratumoral CD70 on the initiation, progression, and immune response in diffuse large B-cell lymphoma (DLBCL) remains poorly understood.

Feb 13, 2023 · We investigate cell surface proteins that could be targeted by antibody-based or adoptive cell therapy approaches and identify CD70 as being highly upregulated in EMT-associated resistance. Moreover, CD70 upregulation is an early event in the evolution of resistance and occurs in drug-tolerant persister cells (DTPCs).

CD70, another methylation-sensitive T cell gene, is the cellular ligand for the tumor necrosis factor (TNF) receptor family member CD27 on B cells. Encoded by gene TNFSF7, CD70 is transiently expressed on the surface of activated lymphocytes.