Dec 12, 2017 · CD68 is a common marker for macrophage lineage cells, primarily localized to microglia within the brain parenchyma, and perivascular macrophages in the cerebral blood vessels and, occasionally...

Feb 7, 2025 · CD68 presence indicates active microglial participation in clearing apoptotic cells and maintaining CNS homeostasis. Studies have highlighted CD68’s importance in facilitating …

CD68 (C luster of D ifferentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia). [5]

Aug 15, 2017 · These results indicate that microglia markers have different potential for neuropathological analysis, with HLA-DR and CD68 reflecting immune activation and response to tissue damage, and Iba1 providing a marker more suited for structural studies in …

Aug 15, 2017 · The aim of this study was to compare the in situ expression of HLA-DR, Iba1 and CD68 in microglia representing different stages of activation in the human brain. Multiple sclerosis (MS) and Alzheimer's disease (AD) pathology were used as principal models.

CD68 is a sialomucin and a member of the scavenger receptor supergene family that is expressed by various types of immune cells, including monocytes, macrophages, dendritic cells, and neutrophils, as well as some non-hematopoietic cells like the epithelium of renal tubules.

Jan 25, 2019 · Deep subcortical lesions (DSCL) of the brain, are present in ~60% of the ageing population, and are linked to cognitive decline and depression. DSCL are associated with demyelination, blood brain barrier (BBB) dysfunction, and microgliosis. Microglia are the main immune cell of the brain.

Jan 25, 2016 · Attention in the present review is focused on microglial markers – proteins (Iba-1, CD11b, CD68, HLA-DR, and others) expressed by microgliocytes in normal conditions and on activation evoked by harmful factors.

Apr 28, 2023 · We identified a significant increase in microglial Iba1 and CD68 expression in the human ALS motor cortex, with microglial CD68 being significantly correlated with pTDP-43 pathology load.

Summary of CD68 (DKFZp686M18236, GP110, LAMP4, SCARD1) expression in human brain tissue. Selective cytoplasmic expression in macrophages.