CD56 (NCAM) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

CD56 is the archetypal phenotypic marker of natural killer cells but can actually be expressed by many more immune cells, including alpha beta T cells, gamma delta T cells, dendritic cells, and monocytes.

Monoclonal Antibody for studying NCAM1. Validated for F, IF, IF, IHC, IHC, IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, NCAM1 (CD56) (E7X9M) XP® Rabbit Monoclonal Antibody (CST #99746) is ready to ship.

Invitrogen Anti-CD56 Monoclonal (56C04), Catalog # MA5-11563. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry (Paraffin) (IHC (P)) and Flow Cytometry (Flow) applications. This antibody reacts with Human, Rat samples. Supplied as 500 µL purified antibody (0.2 mg/mL).

The IHC pattern for CD56 in most SCLCs is strong membranous staining in all tumor cells (Figure 8). In tumors suspected to be SCLC or LCNEC that are TTF1 negative, a p40 stain should be performed to exclude basaloid squamous cell carcinoma.

The antibody is a useful aid for classification of CD56+ T/NK-cell lymphomas. Outside the hematopoietic system, CD56 is expressed in a number of tumors, including neuroblastomas and small cell lung cancer (SCLC).

Oct 4, 2013 · Occurrence of CD56 has in colon adenocarcinoma shown negative correlation to liver metastases and positive correlation to survival. In adenocarcinomas of colorectum, pancreas and biliary tract CD56 has shown a role in the development of perineural invasion.

FLEX Monoclonal Mouse Anti-Human CD56, Clone 123C3, Ready-to-Use (Link), is intended for use in immunohistochemistry (IHC) together with Autostainer Link instruments.

Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides in a tissue transport kit (ARUP supply # 47808).