Jul 15, 2010 · Based on the conserved CD31 expression in the axis of hematopoietic stem/progenitor cells (HSC/HPCs) to endothelial cells, we further sought to determine the comprehensive vasculogenic and angiogenic characteristics of …

Administration of ophiopogonin D increased the abundance of CD31 hi Emcn hi vessels and accelerated bone healing. Conclusions. Our findings confirmed the important role of CD31 hi Emcn hi vessels in bone regeneration and provided a new target to treat bone fracture or promote bone regeneration.

Kim H, Cho HJ, Kim SW, et al. CD31+ cells represent highly angiogenic and vasculogenic cells in bone marrow: novel role of nonendothelial CD31+ cells in neovascularization and their therapeutic effects on ischemic vascular disease.

The non-hematopoietic cell fraction of the bone marrow (BM) is classically identified as CD45 – Ter119 – CD31 – (herein referred to as triple-negative cells or TNCs). Although TNCs are believed to contain heterogeneous stromal cell populations, they remain poorly defined.

Sep 3, 2010 · Based on the conserved CD31 expression in the axis of hematopoietic stem/progenitor cells (HSC/HPCs) to endothelial cells, we further sought to determine the comprehensive vasculogenic and angiogenic characteristics of …

Conclusions: These data indicate that BM-CD31 cells represent highly angiogenic and vasculogenic cells and can be a novel and highly promising source of cells for cell therapy to treat ischemic cardiovascular diseases. (Circ Res. 2010;107:602-614.) Key Words: bone marrow CD31 (PECAM-1) angiogenesis vasculogenesis peripheral vascular disease F

The transplantation of rat PB-CD31+ cells advanced bone tissue restoration in vivo and was associated with an early anti-inflammatory response, the stimulation of (re)vascularization, and reduced fibrosis.

Preliminary flow cytometric analysis showed that CD31, traditionally a marker for endothelial cells, is expressed in certain nonendothelial BM mononuclear cells in both human and mouse.

Based on the conserved CD31 expression in the axis of hematopoietic stem/progenitor cells (HSC/HPCs) to endothelial cells, we further sought to determine the comprehensive vasculogenic and angiogenic characteristics of human and mouse BM-derived CD31 + cells.

Recent studies have identified a specialized subset of CD31 hi endomucin hi (CD31 hi EMCN hi) vascular endothelium that positively regulates bone formation. However, it remains unclear how CD31 hi EMCN hi endothelium levels are coupled to anabolic bone formation.