CD23/FcεRII, the low-affinity receptor for IgE, is constitutively expressed on B cells and has been shown to regulate immune responses. Simultaneous binding of IgE to FcεRI and CD23 is …

CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels.

CD23 has been proposed to participate in both a positive and a negative feedback mechanism in the regulation of IgE synthesis by B cells (3, 4). Human B cells undergo isotype class …

Dec 30, 2020 · The importance of CD23 as a target of IgE is not entirely clear. However, even though CD23 binds IgE with clearly lower affinity compared with FcεRI, It was shown that …

Increasing evidence suggests that the low-affinity receptor for IgE, CD23, plays an important role in controlling the activity of allergen-specific T cells through IgE-facilitated allergen presentation.

Feb 7, 2024 · We propose that CD23 + IGHE + IgG1 + memory B cells are involved in the persistence of food allergy by providing precursors of pathogenic IgE plasma cells. Thus, …

Mar 31, 2017 · Two lectin-like “head” domains of CD23 bind to IgE-Fc with affinities that differ by more than an order of magnitude, but the crystal structure reveals only one head bound to one …

The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcɛRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates …

Sep 7, 2012 · IgE cross-linked by allergen triggers mast cell activation via FcϵRI, whereas IgE-CD23 interactions control IgE expression levels. We have determined the CD23 binding site …

The low affinity IgE receptor, Fc∊RII (CD23), is both a positive and negative regulator of IgE synthesis. The proteinase activity that converts the membrane-bound form of CD23 into a …