CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, [5] LFA-3 receptor, erythrocyte receptor and rosette receptor.

Mar 30, 2025 · Complete information for CD2 gene (Protein Coding), CD2 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

CD2 is a transmembrane molecule belonging to the immunoglobulin supergene family that plays a crucial role in T-cell activation, cytolysis, apoptosis, and cytokine production.

Jun 9, 2020 · The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells.

Feb 15, 1997 · The CD2 glycoprotein has been implicated in both positive and negative regulation of T-cell mitogenesis. To study the involvement of CD2 in T-lymphocyte development and immune responses, we have analyzed two lines of CD2-null mice, each expressing a distinct class I major histocompatibility complex (MHC)-restricted T-cell receptor (TCR).

Jun 9, 2020 · Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more selectively target memory T cells while favoring immune regulation.

The CD2 molecule is a 50-55KD transmembrane glycoprotein expressed on the vast majority of thymocytes and virtually all peripheral T lymphocytes. Its functions are two-fold: adhesion and activation.

CD2 serves as a paradigm for the multitude of adhesion-receptors now being described and characterized. Detailed understanding of each molecule will allow synthesis of an integrated understanding of cellular and molecular interaction during immunity.

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Nov 23, 2023 · Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin. A candidate gene study identifies a haplotype of CD2 as novel susceptibility factor for systemic sclerosis. A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset.