CD160 is an Ig-like glycoprotein expressed by the majority of circulating natural killer cells and γδ T cells. Whether CD160 could regulate CD8 + T-cell functions remains unknown. In this study, we investigated the effects of CD160 on CD8 + T cells in pancreatic cancer.

Nov 1, 2023 · A better understanding of the regulatory mechanisms governing the development of memory CD8+ T cells could provide instructive insights into vaccination strategies and T cell-based immunotherapies. In this article, we showed that CD160 surface protein is required for CD8+ T cell memory formation.

Aug 27, 2018 · In this study, we demonstrate that CD160 has a costimulatory role in promoting CD8 + T cell effector functions needed for optimal clearance of oral Listeria monocytogenes infection. CD160-/-mice did not clear oral L. monocytogenes as …

In this study, we demonstrate that CD160 has a costimulatory role in promoting CD8 + T cell effector functions needed for optimal clearance of oral Listeria monocytogenes infection. CD160 −/− mice did not clear oral L. monocytogenes as efficiently as wild type (WT) littermates.

Sep 11, 2023 · In this study, we investigated the impact of CD160 signaling on CD8 + T cell differentiation upon acute viral infection using mouse models, and our results revealed an indispensable role of CD160 in the memory CD8 + T cell formation after viral infection.

Apr 30, 2021 · We found that CD160 was the most upregulated co-inhibitory receptor in patients with CLL. Its expression was associated with an exhausted T cell phenotype. CD160 + CD8 + T cells were highly antigen-experienced/effector T cells, while CD160 + …

Sep 2, 2014 · Coexpression of CD160 and PD-1 on HIV-specific CD8 + T-cells defines a highly exhausted T-cell subset. CD160 binds to Herpes Virus Entry Mediator (HVEM) and blocking this interaction with HVEM antibodies reverses T-cell exhaustion.

Sep 25, 2014 · We demonstrate that CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression and that the blockade of CD160 signaling may partially restore CD8 T-cell functions.

Aug 27, 2018 · In this study, we demonstrate that CD160 has a costimulatory role in promoting CD8 + T cell effector functions needed for optimal clearance of oral Listeria monocytogenes infection. CD160 −/− mice did not clear oral L. monocytogenes …

CD160 is an Ig-like glycoprotein expressed by the majority of circulating natural killer cells and γδ T cells. Whether CD160 could regulate CD8 + T-cell functions remains unknown. In this study, we investigated the effects of CD160 on CD8 + T cells in pancreatic cancer.