CD137 is a costimulatory molecule functioning to stimulate T cell proliferation, dendritic cell maturation, and promotion of B cell antibody secretion. [7] As a T cell co-stimulator, T cell receptor (TCR) and CD28 signaling causes expression of CD137 on T cell membranes.

6 days ago · Monoclonal Antibody for studying TNFRSF9. Validated for IHC, IHC, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, 4-1BB/CD137/TNFRSF9 (E6Z7F) XP® Rabbit Monoclonal Antibody (CST #19541) is ready to ship.

Invitrogen Anti-CD137 Polyclonal, Catalog # PA5-106494. Tested in Western Blot (WB) and Immunocytochemistry (ICC/IF) applications. This antibody reacts with Human, Rat samples. Supplied as 100 µL purified antibody (1 mg/mL).

4-1BB (CD137) Antibody. Applications: Flow, WB, ELISA, ICC/IF, IHC. Reactivity: Human, Mouse, Rat, Non-human primate, Baboon. Publications: 142. Images: 248. Clonality: Monoclonal, Recombinant Monoclonal, Polyclonal. Conjugates: Unconjugated, PE, …

Interaction of CD137 with its ligand (CD137L, also known as TNFSF9 or 4-1BBL) on activated antigen-presenting cells (APCs) could lead to bidirectional activation that promotes immunity against cancer [3]. For instance, it has been shown that signals through the CD137 receptor could lead to T cell activation and survival [3].

CD137/CD137 ligand (CD137L) signalling primarily induces a potent cell-mediated immune response, while signalling of cell surface-expressed CD137L into antigen presenting cells enhances their activation, differentiation and migratory capacity.

Polyclonal Antibody for studying TNFRSF9. Validated for WB. Highly specific and rigorously validated in-house, 4-1BB/CD137/TNFRSF9 Antibody (CST #62634) is ready to ship.

On the basis of efficacy in mouse tumor models, multiple CD137 (4-1BB) agonist agents are being preclinically and clinically developed. The costimulatory molecule CD137 is inducibly expressed as a transmembrane or as a soluble protein (sCD137).

Invitrogen Anti-CD137 Polyclonal, Catalog # PA1-27993. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Flow Cytometry (Flow) and ELISA (ELISA) applications. This antibody reacts with Human samples. Supplied as 25 µg purified antibody (0.2 mg/mL).

Aug 23, 2024 · Here, we report the development of a small molecular CD137 agonist, JNU-0921. JNU-0921 effectively activates both human and mouse CD137 through direct binding their …