Jul 15, 1998 · The CCR8 ligands I-309 and its mouse homologue T cell activation gene 3 (TCA-3) are potent chemoattractants for Th2-polarized cells. Taken together, these observations strongly suggest that CCR8 plays a role in the control of Th2 responses, and may represent a potential target for treatment of allergic diseases.

Jan 30, 2025 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

Nov 15, 2006 · CCR8 expression is primarily restricted to a subset of human CD4 memory T lymphocytes (15%). Approximately 40% of CCR8+CD4+ T cells express Th2 cytokines IL-4 or IL-13 while 13% express the Th1 cytokine IFN-gamma. In fact, 50% of all Th2, but only 5% of Th1, cells express CCR8.

We used adoptive transfer experiments to compare the trafficking of wild type antigen-specific Th2 cells with antigen-specific Th2 cells deficient in CCR4, CCR8 or CXCR3. CCR4-deficient antigen-specific Th2 cells failed to traffic efficiently into the lung and the airways.

Feb 2, 2005 · CCR8 was initially described as a Th2 cell-restricted receptor, but this has not been fully tested in vivo. The present study used ex vivo and in vivo approaches to examine the distribution and functional significance of CCR8 among CD4 + T cells.

CCL18 induced migration and calcium flux of highly polarized Th2 cells. CCR8 induction in murine Th2 cells at levels high enough to detect agonist function occurs transiently after TCR activation of Th2 cells generated by multiple rounds of polarization (D’Ambrosio et al., …

Jul 15, 1998 · In this paper we report on the cloning and characterization of mouse CCR8. Like its human homologue, it is predominantly expressed in the thymus. In the periphery, murine CCR8 mRNA was found most abundantly expressed in activated Th2 …

Jun 1, 2001 · In vitro polarized human Th2 cells preferentially express the chemokine receptors CCR3, CCR4, and CCR8 and migrate to their ligands: eotaxin, monocyte-derived chemokine (MDC), thymus- and activation-regulated chemokine (TARC), and I-309.

Highly polarized human Th2 cells expressed CCR8, secreted IL-4 and IL-5, and exhibited chemotaxis and calcium flux to CCL18. Furthermore, CCL1, a known CCR8 ligand, and CCL18 induced heterologous cross-desensitization of human Th2 cells, suggesting that they share a common receptor.

Jul 15, 1998 · In this paper we report on the cloning and characterization of mouse CCR8. Like its human homologue, it is predominantly expressed in the thymus. In the periphery, murine CCR8 mRNA was found...