Aug 12, 2022 · CCL22/CCR4 signaling activated the intracellular Ca2+/phospholipase C-γ1 (PLC-γ1) axis to stimulate the phosphorylation of DGKα at a tyrosine residue (Tyr335) and promoted …

Mogamulizumab is a fully humanized and glyco-engineered monoclonal anti-CCR4 antibody used for the treatment of refractory/relapsed ATLL and CTCLs, often resulting in complete …

C–C chemokine receptor type 4 (CCR4), also designated CD194, is a receptor that is specific for the chemokines CCL17 and CCL22. CCR4 is expressed on T-lymphocytes (Th2, Th17, Th22 …

Dec 15, 2022 · Trametinib alleviates anti-CCR4 mAb-induced CTL reduction by downregulating CCR4 expression in CTLs through modulation of TCR signaling. In contrast, trametinib does …

In the present study, we mainly investigated the role played by the CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8 α+ …

Feb 17, 2023 · The CCR4 interaction with CCL12 activates intracellular signaling that activates various pathways such as NF-Kb, RAS-MAPK, JAK-STAT, P13K-AKT-mTOR, and PLC-Ca …

Jun 10, 2024 · The densitometric analysis revealed that proteins CCR4, Dectin2, PLC-γ2, NFATC2, Nr4a2, and PD-L1 were significantly increased in the CCL22-DC group compared …

Nov 4, 2021 · CCR4 is a chemokine receptor mainly expressed by T cells. It is the receptor for two CC chemokine ligands, CCL17 and CCL22. Originally, the expression of CCR4 was …

Two recent studies using the PLC inhibitor U73122 have demonstrated the importance of PLC activation for CXCL12/CXCR4- and CXCL11/ CXCR3-mediated chemotaxis of T cells [25, 45].

Apr 13, 2006 · This study demonstrates that CCL22 and CCL17 stimulate pertussis toxin-sensitive elevation of intracellular calcium in the CEM leukemic T cell line and human peripheral blood …