C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene. [5] CCR1 has also recently been designated CD191 (cluster of differentiation 191). This gene encodes a member of the beta chemokine receptor family, which belongs to …

Jul 28, 2023 · We identified that chemokine receptor-1 (CCR1) is highly expressed on monocytes (Mo) and macrophages (MΦ), and CCR1 pharmacological inhibition or CCR1 siRNA abolished lymphoma-mediated Mo/MΦ migration in a chemotaxis assay. The deficiency of host CCR1 (CCR1 KO) was associated with decreased infiltration of peritoneal-MΦ compared with WT …

Antagonists targeting chemokine-receptor 1 (CCR1) may provide a novel approach for treating multiple myeloma. In vitro CCR1 antagonists display a high degree of specificity, and in some cases signaling bias.

There has been some speculation that CCR1 may play a role in the progression of multiple myeloma (MM) (Karash and Gilchrist, 2011; Vallet and Anderson, 2011).MM is the second most common adult haematological malignancy in the USA with approximately 20 000 new cases and 11 000 deaths annually and accounts for approximately 10% of all haematological cancers …

Mar 30, 2025 · CCR1 (C-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CCR1 include Behcet Syndrome and Corneal Ulcer. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Data suggest that CCR1 gene may be a putative marker of molecular activity of Crohn's disease. Results reveal that CCR1 expression is positively correlated with OPN expression in hepatocellular carcinoma cells, and the patients with high levels of both OPN and CCR1 have the most dismal prognosis.

CCR1 is one chemokine receptor that mediates monocytes trafficking to the site of inflammation when stimulated, particularly by CCL3 and CCL5 [76]. CCR1 is important for controlling the earliest pro-inflammatory events in the border zones of inflammatory brain injury in active MS and advanced EAE [30].

May 15, 2024 · Although CCR1 and CXCR2 on myeloid cells could be involved in tumor progression, it remains elusive what effect would be observed if both of those are blocked. We employed two syngeneic...

Mar 25, 2022 · Antagonists targeting chemokine-receptor 1 (CCR1) may provide a novel approach for treating multiple myeloma. In vitro CCR1 antagonists display a high degree of specificity, and in some cases signaling bias.

Glucocorticoids (GC) are cornerstone drugs in the treatment of multiple myeloma (MM). Because MM cells exploit the bone marrow microenvironment to obtain growth and survival signals, resistance to glucocorticoid-induced apoptosis emerges, yet the underlying mechanisms remain poorly characterized.