Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 performs a multifaceted and versatile functions in multiple biological processes.

A unique evasion mechanism of KSHV reveals that this virus incorporates viral homologs of IRFs (vIRFs) to inhibit IRF7 DNA binding by blocking either the DBD or IAD of IRF7 (Figure 3, right side). In a parallel study by Zhu et al., another inhibitory mechanism of KSHV has been reported.

Dec 20, 2002 · Here, we report that IRF7 is acetylated in vivo by the histone acetyltransferases p300/CBP-associated factor (PCAF) and GCN5. The single lysine residue target for acetylation, lysine 92, is located in the DNA-binding domain and is conserved throughout the entire IRF family.

Sep 1, 2006 · IRF7 is essential for the robust type I IFN gene induction that is elicited by ligation of TLR7 or TLR9, whereas IRF5 is required for the induction of pro-inflammatory cytokine genes....

Oct 9, 2024 · IRF proteins regulate the expression of target genes through their interaction with ISREs or IFN regulatory elements within the DNA. All IRFs feature a highly conserved N-terminal DNA-binding...

Last, IRF7 expression was recently found to be elevated in PBMC from patients with systemic sclerosis, as compared to healthy donors, due to promoter hypomethylation . IRF8 was recently found to play an important role in the differentiation of IL9-producing T helper cells (Th9).

We found that the efficient and self-limiting innate immune response to bacterial infection relies on a tight balance between IRF-3 and IRF-7. Deletion of Irf3 resulted in overexpression of Irf7 and led to an IRF-7–driven hyperinflammatory phenotype, which …

Apr 6, 2009 · IRF-3 expression activates predominantly IFN-A1 and IFN-B, while IRF-7 expression induces multiple IFN-A genes. IFN-A1 gene expression is dependent on three promoter proximal IRF elements (B, C, and D modules, located at positions −98 to −45 relative to the mRNA start site).

IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation. A Quantitative Genetic Interaction Map of HIV Infection. These findings provide further support for the essential role of IRF7 in amplifying antiviral IFN responses to ensure potent and sustained IFN responses during influenza virus infection in humans.

Dec 20, 2002 · Interferon regulatory factor 7 (IRF7) is an interferon-inducible transcription factor required for induction of delayed early interferon α genes and the onset of a potent antiviral state.