C57BL/6, often referred to as "C57 black 6", "B6", "C57" or "black 6", is a common inbred strain of laboratory mouse. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease.

C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.

The C57BL/6 mouse is a multipurpose model that can be used for research into physiology, immunology, safety and efficacy, oncology and genetics, as well as mouse model creation. B6 mice are often preferred to other inbred mice in certain research disciplines such as …

Since C.C. Little (the founder of The Jackson Laboratory) initially generated the C57BL inbred strain in the 1920’s-1930’s, the inbred substrain C57BL/6 became the most frequently used mouse strain in biomedical research.

Jan 3, 2019 · C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. Macrophages from this strain are resistant to the effects of anthrax lethal toxin.

C57BL is probably the most widely used of all inbred strains, (substrain C57BL/6 alone accounts for over 14% of occasions on which an inbred strain is used) though in many ways it seems to be atypical of inbred strains of laboratory mice.

The C57BL/6 mouse model stands as a cornerstone in scientific research, offering invaluable insights that span various fields including genetics, immunology, and pharmacology. Its genetic consistency provides a reliable platform for experimentation, making it highly favored in …

Mar 18, 2025 · View mouse strain C57BL/6 : mutations, QTL, phenotypes, diseases, and references.

The C57BL/6 mouse is a multipurpose model that can be used in such fields as model creation, physiology, safety and efficacy, and genetics. General Purpose - Atochina, E.N. et al. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization.

C57BL/6 mice are invaluable to scientific research, notably serving as the first mammal to have its genome completely sequenced. This milestone, achieved in 2002, has opened new frontiers in genetic research, with the “Black 6” strain serving as a …