C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization: …

Dec 24, 2010 · We present crystal structures of the pro-convertase C3bB at 4 angstrom resolution and its complex with factor D at 3.5 angstrom resolution. Our data show how factor B binding …

C3 is cleaved continuously at a slow rate in the fluid phase, forming C3b, which binds to nucleophilic groups on target surfaces. Activation of C3b causes deposition on the target …

Some of the most fundamental features of C3 biochemistry can be understood by examining the structures of C3, C3b, and C3c, including (i) how the α and β chains relate to one another in …

Dec 24, 2010 · We present crystal structures of the pro-convertase C3bB at 4 angstrom resolution and its complex with factor D at 3.5 angstrom resolution. Our data show how factor B binding …

Oct 15, 2006 · Central to the complement system is the activated form of C3, called C3b, which attaches covalently to target surfaces 3 to amplify complement response, label cells for …

Oct 15, 2006 · Here we present a structure of C3b that reveals a marked loss of secondary structure in the CUB (for ‘complement C1r/C1s, Uegf, Bmp1’) domain, which together with the …

Oct 15, 2006 · Here we present the crystal structure of C3b in complex with CRIg and, using CRIg mutants, provide evidence that CRIg acts as an inhibitor of the alternative pathway of …

We present crystal structures of the pro-convertase C3bB at 4 angstrom resolution and its complex with factor D at 3.5 angstrom resolution. Our data show how factor B binding to C3b …

3 days ago · These pathways, classical (CP), lectin (LP), and alternative (AP), differ in their recognition DAMPs and PAMPs yet converge on the assembly of C3 convertases (CP/LP and …