Factor I can cleave C3b into C3c and C3d, the latter of which plays a role in enhancing B cell responses. In the alternative complement pathway, C3 is cleaved by C3bBb, another form of …

This Review provides a concise classification, summary, and interpretation of the more than 50 unique crystal structure determinations for human C3. It also highlights other salient features …

C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization: …

Dec 12, 2006 · C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement …

Sep 22, 2005 · Activation of component C3 (1,641 residues) is central to the three complement pathways and results in inflammation and elimination of self and non-self targets. Here we …

In our review, we look at the complement system as an archetype of a preformed mediator of host defense and show how nature industriously and elegantly uses a single molecular scaffold, i.e. …

C3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 …

C3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 …

3 days ago · Currently known sources of intracellular C3 Subcellular organelles Nucleus Cytoplasm ER C3b C3D C3 Met Met C3 (a) (b) (c) (d) C3 C3b C3b C3 C3 (e) (f) (g) …

Oct 15, 2006 · Here we present a structure of C3b that reveals a marked loss of secondary structure in the CUB (for ‘complement C1r/C1s, Uegf, Bmp1’) domain, which together with the …