The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the …

The crystal structure of the gC1q, molecular modeling and protein engineering studies have combined to illustrate how modular organization, charge distribution and the spatial orientation …

C1q is the first subcomponent of the C1 complex of the classical pathway of complement activation. Several functions have been assigned to C1q, which include antibody-dependent …

C1q is a complex glycoprotein assembled from 18 polypeptide chains, with a C-terminal globular head region that mediates recognition of diverse molecular structures, and an N-terminal …

C1q has a bouquet-like structure assembled from six collagenous stems, each with a C-terminal globular head. Binding to pathogens induces a conformational change that drives activation of …

Apr 4, 2012 · From a structure–function point of view, the C1q molecule contains two very well defined major functional domains through which it enters into a wide range of molecular …

We report here the x-ray structure of the heterotrimeric globular head of C1q, the domain responsible for the versatile recognition properties of this protein.

Jan 5, 2012 · The 3-D structure of the C-terminal globular domain of human C1q, obtained after digestion of the collagenous moiety of the protein with collagenase, has been solved by X-ray …

Jun 5, 2003 · The structure reveals a compact, almost spherical heterotrimeric assembly held together mainly by non-polar interactions, with a Ca2+ ion bound at the top. The heterotrimeric …

Jan 19, 2017 · C1q consists of six heterotrimers each containing the C1qA, C1qB, and C1qC chains. Each chain has a central region forming a collagen stem together with the equivalent …