The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the …

Here, we discuss the role of C1q in controlling immune cell function, including recently elucidated mechanisms of action, and suggest how these processes are critical for maintaining tissue …

Dec 1, 2021 · When C1q binds to its ligands, such as antibodies on invading pathogens, activation of the classical pathway of the complement system commences. Besides C1q, the …

C1q deficiency is a rare disorder associated with recurrent skin lesions, chronic infections, systemic lupus erythematosus (SLE) or SLE-like diseases. It has also been associated with a …

C1q is a complex glycoprotein assembled from 18 polypeptide chains, with a C-terminal globular head region that mediates recognition of diverse molecular structures, and an N-terminal …

The C1 complex (complement component 1, C1) is a protein complex involved in the complement system. It is the first component of the classical complement pathway and is composed of the …

C1q is the first subcomponent of the C1 complex of the classical pathway of complement activation. Several functions have been assigned to C1q, which include antibody-dependent …

C1q shapes inflammatory responses by influencing cytokine production, cellular recruitment, and tissue remodeling. Its role in apoptotic cell and immune complex clearance prevents excessive …

May 13, 2022 · C1q can interact with various proteins and form protein complexes in particular microenvironments. C1q in human serum binds danger-associated molecular patterns …

The presence of collagen-like triple-helical structures within C1q appears crucial to the presentation, and multivalent binding, of the globular heads of C1q to targets, and also to its …