BW373U86 is a selective agonist for the δ-opioid receptor, with approximately 15× stronger affinity for the δ-opioid than the μ-opioid receptor. [3] It has potent analgesic and antidepressant effects in animal studies.

BW373U86 is a potent and highly selective nonpeptidic agonist for delta-opioid receptors. To determine its ability to couple with G protein-linked second messenger systems, this study examined the effects of BW373U86 on the inhibition of adenylyl cyclase and the stimulation of low-Km GTPase activity …

Feb 21, 1994 · BW373U86 (BW373) is a potent and highly selective non-peptide agonist for δ opioid receptors. In order to determine its ability to activate G-protein-linked second messenger systems, the effects of BW373 on inhibition of adenylyl cyclase (AC) and stimulation of low K m GTPase activity were examined.

(+/-)-4-((alpha-R*)-alpha-((2S*,5R*)-4-Allyl-2,5- dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide (BW373U86) was a potent delta receptor-selective ligand in receptor binding assays. The Ki values were 1.8 +/- 0.4, 15 +/- 3, 85 +/- 4 and 34 +/- 3 nM for delta, mu, epsilon and kappa receptor binding sites, respectively.

BW373U86 was a potent delta receptor-selective ligand in receptor binding assays. BW373U86 inhibited electrically evoked muscle contraction of mouse vas deferens. This inhibitory effect of BW373U86 was antagonized by the delta receptor-selective antagonist naltrindole in a competitive manner.

Oct 1, 1993 · BW373U86 is a potent and highly selective nonpeptidic agonist for delta-opioid receptors. To determine its ability to couple with G protein-linked second messenger systems, this study examined the effects of BW373U86 on the inhibition of adenylyl cyclase and the stimulation of low-Km GTPase activity.

The effect of (+-)-4-((alpha-R*)-alpha-((2S*,5R*)-4-allyl-2,5-dimethyl-1- piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide (BW373U86), the first potent nonpeptidic, highly selective delta opioid receptor agonist, on morphine dependence was studied in rats.

Nov 10, 1994 · Ligand-selectivity studies of the non-peptide 8 agonist, BW373U86, its enantiomers and related compounds showed that these drugs have higher affinities for 8 sites than p sites (4,5). This study determined the selectivity of …

BW373U86 is a potent and highly selective nonpeptidic agonist for delta-opioid receptors. To determine its ability to couple with G protein-linked second messenger systems, this study examined the effects of BW373U86 on the inhibition of adenylyl cyclase and the stimulation of low-Km GTPase activity.

Nov 26, 2003 · Therefore, we examined the ability of the δ -opioid receptor agonist (+)BW373U86 to regulate BDNF and TrkB mRNA expression in frontal cortex, hippocampus, as well as, basolateral amygdala,...