Bufotoxins are a family of toxic steroid lactones or substituted tryptamines of which some are toxic. They occur in the parotoid glands, skin, and poison of many toads (Bufonidae family) and other amphibians, and in some plants and mushrooms. [1][2][3] The exact composition varies greatly with the specific source of the toxin.

Bufotoxin, a moderately potent poison secreted in the skin of many anuran amphibians, especially the typical toads (genus Bufo). The milky fluid contains several identifiable components: bufagin, with effects on the heart similar to those of digitalis; bufotenine, a hallucinogen; and serotonin, a

The bufotoxins are cardiac glycosides. They bind to and inhibit sodium-potassium ATPase in a manner similar to other cardiac glycosides, such as digoxin and digitoxin. The inhibition of the sodium-potassium ATPase results in an increased extracellular concentration of potassium and an increased intracellular concentration of sodium.

2 days ago · Bufotoxin, a complex cocktail of bioactive substances secreted by toads of the Bufo genus (now Rhinella), is more than just a nuisance secretion. It’s a potent defense mechanism, and understanding its effects on humans is crucial for safety and proper medical response. In essence, bufotoxin exposure in humans can lead to a range of symptoms ...

Bufotenin, also known as dimethylserotonin or as 5-hydroxy-N,N-dimethyltryptamine (5-HO-DMT), is a serotonergic psychedelic of the tryptamine family. It is a derivative of the psychedelic dimethyltryptamine (DMT) and of the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT).

The skin-gland secretions of cane toads (called bufotoxin) are highly toxic and can sicken or even kill animals that bite or feed on them, including native animals and domestic pets. The skin secretions may irritate the skin or burn the eyes of people who handle them.

Supportive, symptomatic care might be the main therapies for this poisoning, especially if DsFab is not available. Keywords: toads, bufotoxin, bufadienolide, cardioactive steroids, cardiac glycosides, digoxin-specific antibody fragments.

Bufotoxin | C40H60N4O10 | CID 20054854 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

May 8, 2023 · Bufadienolides, naturally found in toad venoms having steroid-like structures, reveal antiproliferative effects at low doses. However, their application as anticancer drugs is strongly prevented by their Na + /K + -ATPase binding activities.

bufotenine, weak hallucinogenic agent active by intravenous injection, isolated from several natural sources or prepared by chemical synthesis. Bufotenine is a constituent of toad poison, the poisonous, milky secretion of glands found in the skin on the back of the animal. It was first isolated in 1934.