Bcl-2-like protein 11, commonly called BIM (Bcl-2 Interacting Mediator of cell death), is a protein that in humans is encoded by the BCL2L11 gene. [5] [6]

BIM, known as B-cell Lymphoma 2-like protein 11, a molecule belonging to the Bcl-2 family, is involved in the intrinsic pathway of apoptosis [140-142]. BIM enacts cell passing either by contradicting the pro-survival BCL-2 family individuals or by specifically actuating the pro-apoptotic BCL-2 family members [143].

Mar 30, 2025 · The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of ...

Jan 4, 2013 · Proapoptotic Bcl-2 homology 3-only protein Bim plays an important role in Bax/Bak-mediated cytochrome c release and apoptosis. Here, we provide evidence for a novel prosurvival function of Bim in cancer cells.

Background: The BH3-only protein Bim is conventionally considered a proapoptotic protein because it induces Bax/Bak oligomerization on mitochondria. Results: Bim is constitutively up-regulated in cancer cells via an E2F1-dependent mechanism. Silencing of …

Jan 15, 1998 · An expression screen for proteins that bind to Bcl-2 yielded a small novel protein, denoted Bim, whose only similarity to any known protein is the short (nine amino acid) BH3 motif shared by most Bcl-2 homologues.

Bim is a Bcl-2 homology 3 (BH3)-only protein that was discovered by O'Connor et al. in 1998, while screening for proteins binding the anti-apoptotic Bcl-2 protein, giving raise to its name Bcl-2 interacting mediator of cell death.

Know comprehensive Bim protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Apr 9, 2025 · We found two BCL2 transcripts carrying two overlapping open reading frames, one of which is 717 nucleotides long and encodes a protein (BCL2 alpha) of 239 amino acid and a predicted molecular mass ...

Apr 28, 2006 · Our data suggest that Bim is a member of the intrinsically unstructured class of proteins, and that it undergoes a localized conformational change when it binds prosurvival molecules.