Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. [5][6] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules.

Basic fibroblast growth factor (bFGF) is a prototypic member of the fibroblast growth factor family.

Here, we focused on bFGF, which, when secreted by tumor cells, mediates several signal transductions and plays an influential role in tumor cells and in the development of chemoresistance.

Basic FGF (heparin binding growth factor-2, basic brain-derived growth factor) is a 17 kDa member of the family of heparin binding growth factors, which also includes acidic FGF (HBGF-1) as well as the oncoproteins Int-2 (HBGF-3), HST/K53 (HBGF-4), and HBGF-5 (1).

Jun 26, 2018 · Basic Fibroblast Growth Factor (bFGF) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of physiologic angiogenesis....

Here, we summarize data from various tumor types where bFGF is upregulated after anti-angiogenic treatment, the molecular mechanisms involved, and we highlight the current status and future perspectives of multi-target anti-angiogenic drugs for cancer.

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors that includes at least 22 structurally related members, of which acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) are the best-known members.

Basic fibroblast growth factor (bFGF or FGF2), initially identified as a mitogen with prominent angiogenic properties, is now recognized as a multifunctional growth factor (3). It is clear that bFGF produces its biological effects in target cells by signaling through cell-surface FGF receptors. bFGF binds to all four FGF receptors.

Our study demonstrated that bFGF is a compelling regenerative therapy with competitive clinical efficacy and safety for deep second-degree burns and reduced treatment time, which is expected to reduce medical costs, particularly for deep second-degree burn patients.

Feb 19, 1991 · The three-dimensional structure of the 146-residue form of human basic fibroblast growth factor (bFGF), expressed as a recombinant protein in yeast, has been determined by x-ray crystallography to a resolution of 1.8 A. bFGF is composed entirely of beta-sheet structure, comprising a three-fold repeat of a four-stranded antiparallel beta-meander.