Apr 11, 2025 · SignalSilence® Bax siRNA I from Cell Signaling Technology (CST) allows the researcher to specifically inhibit Bax expression using RNA interference, a method whereby gene expression can be selectively silenced through the delivery …

Mar 7, 2008 · In vivo and ex vivo experiments revealed that C2-ceramide increases Bax expression, while PACAP reverses this effect. In vitro tests using cerebellar NPCs demonstrated that the Bax-specific...

Apr 24, 2020 · Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial outer membrane permeabilization...

In the left inside, representative immunoblot (n = 5) of BAX, CDKN1A protein level in A549 cells (treated with lipofectamine alone (Lipo), control siRNA (Cont siRNA) and two different BAX siRNA (#1 and #2).

The protective effect of Bax siRNA was detectable as early as 12 hr post-RESV treatment and the maximal protective effect was observed by 24 hr post-RESV treatment. In contrast, Bax siRNA transfected with X-tremeGENE from Roche caused the highest level of cell death

Small interfering RNA (siRNA) is a critical loss-of-function tool for elucidating the role of genes in biomedical studies. The effective use of siRNA needs transfection technology that delivers siRNA into the correct location of target cells, especially those which are extremely difficult to transfe …

In this study, we show that human papillomavirus E7-loaded dendritic cells transfected with BAK/BAX siRNA downregulate Bak and Bax protein expression and become resistant to killing by T cells, leading to enhanced E7-specific CD8+ T cell activation and antitumor effects in vivo.

In this study, we show that human papillomavirus E7-loaded dendritic cells transfected with BAK/BAX siRNA downregulate Bak and Bax protein expression and become resistant to killing by T cells, leading to enhanced E7-specific CD8 + T cell activation and antitumor effects in vivo.

Feb 21, 2007 · DCs expressing intact E7 or Sig/E7/LAMP-1 became resistant to attack by CD8 + T cells after transfection with BAK/BAX siRNA, leading to enhanced E7-specific T cell activation in vitro and in vivo.

SignalSilence ® Bax siRNA II from Cell Signaling Technology (CST) allows the researcher to specifically inhibit Bax expression using RNA interference, a method whereby gene expression can be selectively silenced through the delivery of double stranded RNA molecules into the cell.