BAK/BAX macropores facilitate mitochondrial herniation and ... - Science
Feb 23, 2018 · Using a combination of live-cell lattice light-sheet microscopy, 3D structured illumination microscopy, correlative light electron microscopy, and electron cryotomography, …
Bax and Bak Pores: Are We Closing the Circle? - ScienceDirect
Apr 1, 2017 · In the mitochondria of apoptotic cells, Bax clusters into heterogeneous structures including arcs and rings that are associated with membrane pores. Bax shuttles between the …
Endogenous BAX and BAK form mosaic rings of variable size and ...
Mar 19, 2024 · Combining live- and fixed-cell STED super-resolution microscopy, we show that overexpression of BAK results in novel BAK structures, which are virtually absent in non …
Lipid unsaturation promotes BAX and BAK pore activity during …
Jun 3, 2024 · Here, lipidomics and other data provide insight on how local lipid environment affects BAX and BAK function during apoptosis, suggesting that unsaturated lipids promote …
Building blocks of the apoptotic pore: how Bax and Bak are
Oct 25, 2013 · Two key members of the Bcl-2 family are the proapoptotic proteins Bax and Bak, which convert from harmless monomers into deadly oligomers that form pores in the MOM. …
Building blocks of the apoptotic pore: how Bax and Bak are …
Two key members of the Bcl-2 family are the proapoptotic proteins Bax and Bak, which convert from harmless monomers into deadly oligomers that form pores in the MOM. These pores are …
Pore formation by dimeric Bak and Bax: an unusual pore?
Jun 19, 2017 · Here, we review how clusters of dimers and their lipid-mediated interactions provide a molecular explanation for the heterogeneous assemblies of Bak and Bax observed …
The interplay between BAX and BAK tunes apoptotic pore growth …
Mar 3, 2022 · BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial outer membrane permeabilization. However, the mechanism by which they …
The interplay between BAX and BAK tunes apoptotic pore growth …
Mar 3, 2022 · BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial outer membrane permeabilization. However, the mechanism by which they …
Creation of distinctive Bax-lipid complexes at mitochondrial
Jun 2, 2023 · Here, we show that Bax creates pores by extracting lipids from outer mitochondrial membrane mimics by formation of Bax/lipid clusters that are deposited on the membrane surface.