Jul 7, 2014 · The levels of TGF-β1 in BALF were significantly higher in patients with lung cancer compared with patients with benign diseases (P = 0.003). However, no significant difference of IL-6 (P = 0.61) or TNF-α (P = 0.72) in BALF was observed …

Jul 7, 2014 · Changes of cytokines in bronchoalveolar lavage fluid (BALF) reflect immunologic reactions of the lung in pulmonary malignancies. Detection of biomarkers in BALF might serve as an important method for differential diagnosis of lung cancer.

TGF-β1 in the BALF is largely responsible for procollagen I promoter activation. Primary cultures of normal human lung fibroblasts were transiently transfected with the human procollagen I promoter- luciferase plasmid construct.

Oct 3, 2022 · Here, by studying the effects of ECP, we uncovered immune mechanisms that promote BOS after lung transplantation. ECP inhibits BOS through reducing AM responses to TGF-β and lowering intragraft TGF-β bioavailability by inducing DCN expression.

Methods: Total TGF-beta (1) was measured in BALF from 30 pediatric CF patients and 12 non-CF disease controls undergoing clinically indicated flexible bronchoscopy, and compared to four indicators of clinical disease: infection, inflammation, …

With previous studies demonstrating that increased expression of TGF-β can be associated with both acute and chronic lung injury, (24) we explored the association between increased TGF-β as well as PC concentrations in the BALF, and the long-term outcome of BOS.

Oct 3, 2013 · In our current study, we detected the levels of IL-17 and TGF-β1 in the serum and bronchoalveolar lavage fluid (BALF) of asthma infants, with an attempt to explore the role of IL-17 and TGF-β1 in the pathogenesis of asthma and its clinical significance.

The aim of this study was to evaluate TGF-beta1 levels and lymphocyte subsets in the broncholaveolar lavage fluid (BALF) of patients with primary lung cancer and to analyze the interdependence of these parameters.

Sep 15, 2011 · The levels of IL-17A and IL-17A production-related cytokines TGF-β1, IL-6, and IL-23 were significantly elevated in the BALF from the fibrotic lungs (A). The expressions of the transcription factor RORγt and the IL-17R were upregulated in the fibrotic lung tissues (B).

TGF‐β1 plays a critical role in the resolution of tissue injury and development of pulmonary fibrosis (Pittet et al., 2001), and its concentration is markedly increased in BALF as early as 24 h after the onset of ARDS (Burnham et al., 2014).