Aug 7, 2017 · BTA-EG 4 significantly reduced tau phosphorylation in the absence of any changes in the amounts of amyloid precursor protein, amyloid-β or synaptic proteins. The reduction in tau...

May 29, 2013 · The tetra(ethylene glycol) derivative of benzothiazole aniline, BTA-EG4, is a novel amyloid-binding small molecule that can penetrate the blood-brain barrier and protect cells from Aβ-induced toxicity.

BTA-EG4 is a probe for β-amyloid aggregates and an inhibitor of protein-amyloid interaction. BTA-EG4 inhibits several different Ab -binding proteins from associating with aggregated Ab peptides. It inhibits catalase-Aβ binding interactions in solution by forming protein-resistant surface coatings on aggregated Aβ (1–42) peptides.

May 23, 2024 · For example, in the case of BTA-EG4, the aliphatic spacer in the middle comprises hydrophobic segments, while three hydrophilic tetraglycol moieties are used for end-capping in an aqueous environment, facilitating the formation of a substantial planar structure.

Jul 7, 2022 · We present the integration of two reentrant phase transitions based on an unexpected dilution-induced assembly process using supramolecular polymers and surfactants. The co-assembly of the water-soluble benzene-1,3,5-tricarboxamide (BTA-EG 4) and a surfactant at a specific ratio yielded small-sized aggregates.

Nov 20, 2013 · The catalase inhibitor 3-amino-1,2,4-triazole (3-AT) and catalase-amyloid interaction inhibitor benzothiazole aniline tetra(ethylene glycol) (BTA-EG4) significantly enhanced neurotoxicity of amyloid peptides in catalase overexpressing neuronal cells.

BTA-EG4 significantly reduced tau phosphorylation in the absence of any changes in the amounts of amyloid precursor protein, amyloid-β or synaptic proteins. The reduction in tau...

BTA-EG4 is a catalase-amyloid interaction inhibitor, which can significantly enhance the neurotoxicity of amyloid peptides in catalase-overexpressing neuronal cells, and can be used in the study of neurodegenerative diseases.

Aug 7, 2017 · BTA-EG 4 significantly reduced tau phosphorylation in the absence of any changes in the amounts of amyloid precursor protein, amyloid-β or synaptic proteins. The reduction in tau phosphorylation was associated with inactivation of the Alzheimer’s disease-relevant major tau …

Aug 7, 2017 · BTA-EG 4 significantly reduced tau phosphorylation in the absence of any changes in the amounts of amyloid precursor protein, amyloid-β or synaptic proteins. The reduction in tau phosphorylation was associated with inactivation of the Alzheimer's disease-relevant major tau …