BRCA Gene Changes: Cancer Risk and Genetic Testing
A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Evidence-based, expert-reviewed summary about the BRCA1 and BRCA2 genes and hereditary breast and ovarian cancer. This summary also contains information about the cancer risks …
Hoja informativa sobre los cambios en el gen BRCA y las pruebas …
En Esta Página ¿Qué son el BRCA1 y el BRCA2? ¿Cuánto aumenta el riesgo de cáncer de mama o cáncer de ovario si hay un cambio dañino hereditario en BRCA1 o en BRCA2? ¿Qué …
Definición de gen BRCA2 - Diccionario de cáncer del NCI
Gen que da origen a una proteína que repara el ADN dañado. Las mutaciones (cambios) en el gen BRCA2 aumentan mucho el riesgo de presentar cáncer de mama y cáncer de ovario. …
MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes
Apr 15, 2024 · For women in whom gene testing finds “harmful changes” in the BRCA1 or BRCA2 genes, leading medical groups recommend that they take specific actions to lower their …
Researchers categorize thousands of BRCA2 mutations as …
Feb 14, 2025 · A team of researchers led by Shyam K. Sharan, Ph.D., Senior Investigator in the Mouse Cancer Genetics Program, has categorized over 6,500 possible single nucleotide …
Olaparib Approved for Breast Cancers with BRCA Gene Mutations
Jan 29, 2018 · The Food and Drug Administration has approved olaparib (Lynparza®) to treat metastatic breast cancers that have inherited mutations in the BRCA1 or BRCA2 genes as …
PALB2 and Associated Cancer Risks (PDQ®) - NCI
Feb 14, 2025 · However, individuals with PALB2 and BRCA2 pathogenic variants have higher rates of triple-negative breast cancer. PALB2 pathogenic variants are also associated with …
Discovery – BRCA Connection to Breast and Ovarian Cancer
NCI-funded research helped identify inherited BRCA1 and BRCA2 genetic mutations and their connection to breast and ovarian cancer. From this research, a screening test was also …
Surgery to Reduce the Risk of Breast Cancer Fact Sheet
Jan 31, 2025 · Bilateral mastectomy has been shown to reduce the risk of breast cancer by at least 95% in women who have a harmful (disease-causing) variant in the BRCA1 gene or the …