BRCA1 and BRCA2: different roles in a common pathway of …
The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and BRCA2, work in a common pathway of genome protection. However, the two proteins work at different …
The role of BRCA1 in DNA damage response - PMC
The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, …
BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic ...
In mammalian cells, homologous recombination (HR) and non-homologous end-joining (NHEJ) are two major repair pathways to repair DNA double-strand breaks (DSBs) for genome …
BRCA1 - Wikipedia
High BRCA1 may protect cancer cells by acting in a pathway that removes the damages in DNA introduced by the platinum drugs. Thus the level of BRCA1 expression is a potentially …
BRCA Pathway and Its Role in DNA Repair and Cancer Risk
Mar 21, 2025 · BRCA1 detects DSBs and recruits repair factors. It interacts with the MRN complex (MRE11-RAD50-NBS1), which processes broken DNA ends to generate single …
BRCA1 Pathway - Abeomics
BRCA1 is a tumor suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. Loss of the tumor suppressor BRCA1 results in profound chromosomal …
BRCA1: a key player at multiple stages of homologous ... - Springer
May 27, 2021 · BRCA1 directs DSB repair pathway choice towards HR by promoting DNA end resection that generates single-stranded DNA (ssDNA). BRCA1 also facilitates the formation …
BRCA1 levels and DNA-damage response are controlled by the …
Oct 9, 2024 · BRCA1 functions in several crucial cellular pathways that preserve genome stability, including DNA-damage-induced cell-cycle checkpoint activation, DNA-damage repair, …
Signaling Pathway Alterations Driven by BRCA1 and BRCA2 …
Jan 5, 2024 · Signaling pathway alterations in epithelial cells unique to BRCA1 mutations included STAT3, BRD4, SMARCA4, HIF2A/EPAS1, and Inhibin A signaling. BRCA2 mutations were …
BRCA1 pathway function in basal-like breast cancer cells
The role of BRCA1 in the repair of double-strand DNA breaks by homologous recombination (HR) is its best understood function and the function most often implicated in BRCA1 breast cancer …
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