Three domains of the BRCA1 protein are mutated in cancer patients with relatively high frequency. These domains include the RING domain (exons 2-7), a region encoded by exons …

The BRCA1 protein contains the following domains: [24] Zinc finger, C3HC4 type (RING finger) BRCA1 C Terminus domain; This protein also contains nuclear localization signals and …

The domain structure of BRCA1. The RING domain in blue, the two NLS domain in red, the coiled coil domain in orange, and the two BRCT domains in green. BRCA1 can form four different …

BRCA1 is a pleiotropic DDR protein that functions in both checkpoint activation and DNA repair, whereas BRCA2 is a mediator of the core mechanism of homologous recombination.

To characterize functional aspects of the BRCA1/BARD1 interaction, we have defined the structural domains required for the interaction, as well as their oligomerization state, relative …

May 9, 2004 · BRCA1 is a large, modular protein of 1,863 residues containing an N-terminal RING domain, a central region rich in SQ and TQ dipeptide pairs and tandem BRCT (BRCA1 …

Oct 28, 2011 · The BRCA1 protein is composed of several interaction surfaces, each represented by a specific domain. The first 110 amino acids of BRCA1 comprise the RING domain, the …

Oct 4, 2018 · In vivo, BRCA1 exists as a heterodimer with the BARD1 tumor suppressor, and both proteins harbor a phosphate-binding BRCT domain. Here, we compare mice with mutations …

Mar 4, 2024 · Mutations within the BRCT domain can disrupt the normal function of BRCA1 and lead to an increased risk of developing breast and ovarian cancer. Herein, we explore the …

To determine how the BARD1 BRCT domain contributes to BRCA1/BARD1 function, we have characterized mice with mutations (S563F and K607A) that disrupt its phosphate-binding …