BRCA1 is part of a protein complex that repairs DNA when both strands are broken. When this happens, it is difficult for the repair mechanism to "know" how to replace the correct DNA …

Jul 27, 2024 · BRCA1, a breast cancer susceptibility gene, has emerged as a central mediator that brings together multiple signaling complexes in response to DNA damage.

BRCA1 can form four different complexes: BRCA1/RAP80/Abraxas complex, BRCA1/BACH1 complex, BRCA1/PALB2/BRCA2 complex and BRCA1/CtIP complex. The BRCT domain is …

Oct 31, 2020 · The K63-linkage specific deubiquitinase BRCC36 forms the core of two multi-subunit deubiquitination complexes: BRCA1-A and BRISC. BRCA1-A is recruited to DNA …

Taken together these recent studies provide firm evidence that the BRCA1 A-Complex fine-tunes the repair function of BRCA1 by repressing excessive resection in a BRCT dependent manner.

Apr 15, 2000 · We find that BRCA1, the BLM helicase, and the RAD50-MRE11-NBS1 complex colocalize to large nuclear foci that contain PCNA when cells are treated with agents that …

Sep 11, 2024 · Using purified recombinant proteins, we show here that BRCA1–BARD1 directly promotes long-range DNA end resection pathways catalysed by the EXO1 or DNA2 …

May 27, 2021 · BRCA1 localizes to DSB specifically in S/G2 phase of the cell cycle and promotes HR at multiple stages. BRCA1 directs DSB repair pathway choice towards HR by promoting …

Dec 23, 2011 · BRCA1 is a pleiotropic DDR protein that functions in both checkpoint activation and DNA repair, whereas BRCA2 is a mediator of the core mechanism of homologous …

May 8, 2014 · BRCA1 functions to maintain genomic integrity by forming multiple protein complexes with different functions. Here, Savage et al. report the identification of a BRCA1 …