Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1).

Mar 30, 2025 · BMI1 (BMI1 Proto-Oncogene, Polycomb Ring Finger) is a Protein Coding gene. Diseases associated with BMI1 include Mantle Cell Lymphoma and Leukemia. Among its related pathways are Transport of the SLBP independent Mature …

Apr 29, 2009 · Here we demonstrate that Bmi1 can separately regulate mitochondrial function, reactive oxygen species (ROS) levels and the activation of the DNA damage response (DDR) pathway.

Preponderance of evidences indicates that deregulated expression of PcG protein BMI1 is associated with several human malignancies, cancer stem cell maintenance, and propagation. Importantly, overexpression of BMI1 correlates with therapy failure …

Jan 25, 2025 · Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma. BMI1 acts as an oncogene and Mel-18 functions as a tumor suppressor via downregulation of BMI1. EZH2 and BMI-1 are upregulated in osteosarcoma.

In summary, our findings suggest that βTrCP regulates turnover of BMI1 and its function relevant to oncogenesis, cellular senescence and aging. Key words: BMI1, βTrCP, polycomb group proteins, senescence, breast cancer.

Overexpression of BMI-1 has been identified in various human cancer tissues and is known to be involved in cancer cell proliferation, cell invasion, distant metastasis, chemosensitivity and patient survival.

Nov 9, 2016 · BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data support a role of BMI1 in cancer. The central domain of BMI1 is involved in protein–protein interactions...

Bmi-1 is a member of the Polycomb Repressor Complex1 that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells.

Jan 4, 2025 · Title: Bmi-1 promotes the proliferation, migration and invasion, and inhibits cell apoptosis of human retinoblastoma cells via RKIP. Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a …