Tetrahydrobiopterin (BH4, THB), also known as sapropterin (INN), [5][6] is a cofactor of the three aromatic amino acid hydroxylase enzymes, [7] used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrin...

Feb 16, 2024 · Tetrahydrobiopterin (BH4, sometimes THB) is a vital cofactor for numerous enzymes in the body, including those involved in forming nitric oxide (NO), and the key neurotransmitters dopamine, serotonin and epinephrine.

May 18, 2024 · BH4 is an essential cofactor in the formation of nitric oxide from l-arginine. The reaction that produces endothelial nitric oxide involves the eNOS (nitric oxide synthase) enzyme plus BH4 as a cofactor.

Tetrahydrobipterin (BH4) is a pivotal enzymatic cofactor required for the synthesis of serotonin, dopamine and nitric oxide. BH4 is essential for numerous physiological processes at periphery and central levels, such as vascularization, ...

Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the metabolism of phenylalanine and lipid esters.

BH4 plays an essential function as a cofactor of a set of metabolic enzymes, including NOS, four aromatic amino acid hydroxylases, alkylglycerol monooxygenase (AGMO), and the brain-specific tryptophan hydroxylase isomer TPH2.

Sep 15, 2011 · BH4 (6R-L-erythro-5,6,7,8-tetrahydrobiopterin) is an essential cofactor of a set of enzymes that are of central metabolic importance, including four aromatic amino acid hydroxylases, alkylglycerol mono-oxygenase and three NOS (NO synthase) isoenzymes.

Apr 24, 2024 · BH4 plays a critical role in the synthesis of dopamine, serotonin, and nitric oxide, neurotransmitters essential for healthy neurological function. In the synthesis of dopamine, BH4 acts as a cofactor for the enzyme tyrosine hydroxylase, which converts tyrosine to L-DOPA, a precursor of dopamine.

Tetrahydrobipterin (BH4) is a pivotal enzymatic cofactor required for the synthesis of serotonin, dopamine and nitric oxide. BH4 is essential for numerous physiological processes at periphery and central levels, such as vascularization, inflammation, glucose homeostasis, regulation of oxidative stre …

Sep 28, 2018 · The most well-established human function of tetrahydrobiopterin (BH4) is as the cofactor for phenylalanine-4-hydroxylase (PAH), tyrosine-3-hydroxylase, and tryptophan-5-hydroxylase. The...