The BH3 interacting-domain death agonist, or BID, gene is a pro- apoptotic member of the Bcl-2 protein family. [5] Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero- or homodimers.

BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1-3 pro-apoptotic proteins such as BAX and BAK, while their activity is suppressed by BH1-4 anti-apoptotic BCL-2 family members.

Exposure to stress results in the induction of BH3-only proteins, which neutralise the pro-survival proteins. Subsequent activation of BAX and BAK, which involves their conformational change and homo-oligomerisation on the mitochondrial outer membrane, leads to its permeabilisation.

Jul 30, 2009 · It is also accepted that stress signals activate selected Bcl-2 homology (BH)3-only proteins. But do these BH3-only proteins bind and activate Bax and Bak directly, or do they inhibit the...

A BH3 protein is defined as a type of protein that contains BH3 motifs which bind and regulate Bcl-2 homologs, playing a crucial role in cellular responses to stress-induced cues and cell death regulation in the field of Neuroscience.

Oct 5, 2016 · BH3-only proteins monitor cellular wellbeing. BH3-only proteins are activated by a variety of cellular stresses. Once activated, they initiate apoptosis by binding and neutralizing Bcl-2 pro-survival proteins via their BH3 domain (red triangle).

Jan 1, 2017 · BH3-only proteins are proapoptotic members of the broader Bcl-2 family, which promote cell death by directly or indirectly activating Bax and Bak. The expression of BH3-only proteins is regulated both transcriptionally and posttranscriptionally in a cell type-specific and a tissue-specific manner.

Sep 1, 2002 · BH3-only proteins, of which there are at least eight in mammalian cells, serve to integrate diverse apoptotic stimuli into a common cell death pathway governed by BCL-2 and its multi-BH domain relatives (Bouillet and Strasser, 2002).

Jul 30, 2009 · BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1–3 pro-apoptotic proteins such as BAX and BAK,...

BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1-3 pro-apoptotic proteins such as BAX and BAK, while their activity is suppressed by BH1-4 anti-apoptotic BCL-2 family members.