The BH3 interacting-domain death agonist, or BID, gene is a pro- apoptotic member of the Bcl-2 protein family. [5] Bcl-2 family members share one or more of the four characteristic domains …

The BH3-only subset of the Bcl-2 family of proteins contain only a single BH3-domain. The BH3-only members play a key role in promoting apoptosis. The BH3-only family members are Bim, …

Mar 30, 2025 · BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include Colon Adenocarcinoma and Gastric Adenocarcinoma. Among its …

BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1-3 pro-apoptotic proteins such as BAX and …

Feb 8, 2025 · This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 …

May 24, 2022 · This review aims to clarify the key features of BH3 motifs and the structural determinants of currently known BH3-mediated interactions and their implication for structural …

We present evidence in this study that bbc3 is a strongly proapoptotic BH3-only gene that is subject to transcriptional regulation by multiple cell death-signaling pathways.

Within the BCL-2 family exists a subclass of pro-apoptotic members termed the BH3-only proteins, which directly and/or indirectly functionally regulate the remaining anti- and pro …

Feb 8, 2025 · This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 …

A BH3 protein is defined as a type of protein that contains BH3 motifs which bind and regulate Bcl-2 homologs, playing a crucial role in cellular responses to stress-induced cues and cell …