Activity-dependent secretion of BDNF from presynaptic site (red in A and C) may be necessary for E-LTP, while the long-term maintenance of L-LTP requires sustained supply of BDNF through activity-dependent transcription and translation in the postsynaptic neurons (green in B and C).

Brain-derived neurotrophic factor (BDNF) has emerged as a regulator of stable, late phase long-term potentiation (L-LTP) at excitatory glutamatergic synapses in the adult brain. However, the mechanisms by which BDNF triggers L-LTP are controversial.

In addition, studies also show that BDNF is an important regulator of synaptic transmission and long-term potentiation (LTP) in the hippocampus and in other brain regions. The effects of BDNF on LTP are mediated by the TrkB receptor.

Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It is widely expressed in the CNS, gut and other tissues.

Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory. The effects of BDNF in LTP are mediated by TrkB (tropomyosin-related …

The effects of brain-derived neurotrophic factor (BDNF) in long-term synaptic potentiation (LTP) are thought to underlie learning and memory formation and are partly mediated by local protein synthesis.

Mar 3, 2002 · This effect, termed BDNF-induced LTP (or BDNF-LTP), provides a tool for elucidating BDNF mechanisms in synaptic plasticity. If BDNF participates in triggering late LTP, it should somehow regulate new protein synthesis.

Feb 18, 2016 · Acute BDNF infusion induced long-term potentiation (LTP) of medial perforant path-evoked synaptic transmission and, concomitantly, enhanced hippocampal neurogenesis bilaterally,...

Dec 27, 2021 · In this review, we examine the importance of spatial and temporal factors on BDNF activity, particularly in processes such as synaptogenesis, Hebbian plasticity, homeostatic plasticity, and the treatment of psychiatric disorders.

In addition to TBS-induced release of BDNF in hippocampal preparations, many other studies have analyzed the role of endogenously released BDNF in TBS-induced LTP, by either scavenging extracellular BDNF with superfusion of cells with selective BDNF antibodies, or by quantifying released BDNF by ELISA measurements in other brain regions.