Jan 28, 2022 · Brain-derived neurotrophic factors (BDNFs) play an important role in maintaining synaptic plasticity in learning and memory. Considering AD as a synaptic disorder, BDNF has attracted increasing attention as a potential diagnostic biomarker …

The obvious suggestion is that a BDNF deficiency, resulting from a series of different factors, could shape the onset of AD neurodegeneration. These factors would include metal dyshomeostasis, lack of NGF support, loss of functional Aβ …

Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous system and in sensory structures including olfactory and auditory systems. Many studies have highlighted the protective effects of BDNF in the brain, showing how ...

We will discuss the interaction between BDNF and amyloid beta (Aβ) peptide, the effect of BDNF on synaptic repair in AD, and the association between BDNF polymorphism and AD risk.

Oct 4, 2016 · Reduced expression of brain-derived neurotrophic factor (BDNF) has a crucial role in the pathogenesis of Alzheimer’s disease (AD), which is characterized with the formation of neuritic...

Jan 1, 2017 · These properties of BDNF have led to speculations about its role in Alzheimer's disease (AD) where synaptic and neuronal loss and impaired memory constitute an essential part of the pathology.

Brain-derived neurotrophic factor (BDNF) is the most abundant and well-studied neurotropin in mammalian brains. Because of its important role in synaptic plasticity, it is one of the potential therapeutic targets in AD.

Mar 21, 2019 · Using a cross-validation approach, we first explored in subjects with autosomal dominant AD (ADAD) from the Dominantly Inherited Alzheimer Network (DIAN) the effect of BDNFVal66Met on...

Aug 1, 2007 · Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD. BDNF is an endogenous protein involved in the maintenance of neuronal function, synaptic plasticity and structural integrity in the adult brain.

Oct 30, 2014 · Various lines of evidence indicate that BDNF deficit plays a crucial role in the pathogenesis of AD, and bright proofs of the positive effects of BDNF supplement suggesting BDNF may be considered as a valuable therapeutic candidate in AD.