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Feb 28, 2024 · We first developed a blood-brain barrier-in-a-CUBE by layering astrocytes, pericytes, and brain microvascular endothelial cells in the CUBE, and confirmed the expression and function of...

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Feb 28, 2024 · The “Tissue-in-a-CUBE” is a small cubic structure that could provide a boost in the drug discovery field and be used as an alternative to animal models in pre-clinical studies. The study was published in Communications Biology on February 28.

We first developed a BBB-in-a-CUBE model by co-culturing primary astrocytes and peri-cytes in a basement membrane hydrogel (Matrigel) with iPSC-derived BMECs seeded on the top surface of the...

Jan 7, 2022 · The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered therapeutic molecules into the brain.

We first developed a blood-brain barrier-in-a-CUBE by layering astrocytes, pericytes, and brain microvascular endothelial cells in the CUBE, and confirmed the expression and function of important tight junction and transporter proteins in the blood-brain barrier model.

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Jan 18, 2024 · We first developed a blood-brain barrier-in-a-CUBE by layering astrocytes, pericytes, and brain microvascular endothelial cells in the CUBE, and confirmed the expression and function of important tight junction and transporter proteins in the blood-brain barrier model.

Feb 27, 2023 · We first developed a blood-brain barrier (BBB)-in-a-CUBE by layering astrocytes, pericytes, and brain microvascular endothelial cells in the CUBE, and confirmed the expression and function of important tight junction and transporter proteins in the BBB model.