Jun 21, 2013 · BATF is required for the production of interleukin-17 (IL-17), IL-21, IL-22 and IL-23 receptor in T helper 17 (T H 17) cells. In T H 17 cells, BATF is thought to function as a 'pioneer factor'...

GATA-3 and CTLA-4 respond to distinct signal strengths. We examined expression of BATF, IRF4, GATA-3 and CTLA-4 in T H 2 cells activated with a graded level of TCR signaling.

May 18, 2011 · The transcription factor BATF directly regulates key components of the formation and function of follicular helper T cells and antibody class switching in B cells. The production of long-lived...

May 15, 2011 · Here we report the mechanism by which BATF controls in vivo class-switch recombination (CSR). In T cells, BATF directly controlled expression of the transcription factors Bcl-6 and c-Maf, both...

Aug 15, 2017 · Our findings identify BATF as a critical regulator of tissue Treg cells and suggest that sequence-specific perturbations of Foxp3-DNA interactions can influence specific facets of Treg cell physiology and the immunopathologies they regulate.

Jan 14, 2022 · Using single-cell RNA sequencing of pulmonary ILCs from mice recovering from influenza infection, Wu et al. identified a proliferative ILC2 subset enriched for expression of wound healing genes and the transcription factor BATF.

Liu et al. show that basic leucine zipper ATF-like transcription factor (Batf) is a critical regulator of ILC development. IL-7 induces Batf expression in α-lymphoid progenitors, and Batf activates transcription of the Nfil3 gene, which induces ILC hematopoiesis.

Gata3 and Ctla4 are known target genes of IRF4 and BATF 13,14,28 , but were induced at different strengths of TCR signaling (Fig. 1b). GATA-3 was induced at low signal strength, while CTLA-4...

The GATA transcription factor family consists of six DNA-binding proteins (GATA1-6) that regulates transcription of DNA due to their ability to bind to the DNA sequence "GATA" which can therefore affect different diseases.

The transcription factor Batf controls T H 17 differentiation by regulating the expression of both RORγt and RORγt target genes such as Il17. Here, we report the mechanism by which Batf controls in vivo class switch recombination (CSR).