Our data demonstrate that B220 is expressed in a select subset of normal, reactive B cells in a pattern that is consistent with a marker of naive B cells. However, this restricted expression pattern is not seen in B-cell lymphoproliferative disorders.

Choose from 1 of 107 B220 (CD45R) antibodies, which have been validated in experiments with 4165 publications and 1286 images featured in our data gallery. Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications.

Anti-mouse/human CD45 also known as B220. Functional overview of this B cell lineage and mature B cell marker; Anti-mouse CD45R antibody clone RA3-6B2 described.

65139-1-Ig targets CD45R (B220) in IF/ICC, FC applications and shows reactivity with mouse samples. PBS with 0.09% sodium azide. Store at 2-8°C. Stable for one year after shipment.

Jan 1, 2005 · B220 is an isoform of CD45 that is a well-known pan B-cell marker in mice. Recently, it has been found that monoclonal antibodies that recognize murine B220 also recognize a cell surface antigen expressed in a subset of human T and B lymphocytes.

In the present study, we show the expression of B220 on thymocytes undergoing apoptosis induced by X-irradiation and a synthetic glucocorticoid, dexamethasone (DEX). The B220 detected on apoptotic thymocytes was not biochemically distinct from the 220 000-MW CD45 isoform expressed on B cells.

CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Fas lpr and MRL-Fas gld mice. It plays a critical role in TCR and BCR signaling.

Dec 23, 2002 · In summary, we found the expression of a glycosylation-dependent CD45 isoform that is linked to the acquisition of the memory B-cell marker, CD27. B220 constituted a differentiation state-dependent CD45 isoform, akin to the CD45 isoform-based distinction between naive and memory T cells.

Feb 10, 2010 · CD45 is expressed on all hematopoietic cells, and is also known as leukocyte common antigen (LCA). Forms of CD45 with restricted cellular expression are designated CD45RO, CD45RA, CD45RB (http://en.wikipedia.org/wiki/PTPRC). CD45R that has a molecular weight of 220 kDa is commonly known as B220.

Taken together, our findings indicate that the B220 + subset is a distinct subset of Gr1 + CD11b + cells functionally different from the B220 − subpopulation during tumorigenesis and induction of MDSCs to B220 + cells may be helpful for cancer therapy. KEYWORDS: MDSCs, B220, tumor, metastasis, IL-6. 1. Introduction.