Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene. [5][6][7] Transcriptional regulator ATRX contains an ATPase / helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins.

The ATRX gene provides instructions for making a protein that plays an essential role in normal development. Although the specific function of the ATRX protein is unknown, studies suggest that it helps regulate the activity (expression) of other genes through a …

Mar 30, 2025 · ATRX (ATRX Chromatin Remodeler) is a Protein Coding gene. Diseases associated with ATRX include Alpha-Thalassemia Myelodysplasia Syndrome and Intellectual Disability-Hypotonic Facies Syndrome, X-Linked, 1. Among its related pathways are Diseases of Telomere Maintenance and Chromosome Maintenance.

Alpha-thalassemia mental retardation syndrome (ATRX), also called alpha-thalassemia X-linked intellectual disability syndrome, nondeletion type or ATR-X syndrome, [1] is an X-linked recessive condition associated with a mutation in the ATRX gene. [2] Males with this condition tend to be moderately intellectually disabled and have physical …

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, especially in glioma, and recent findings indicate roles for ATRX in key molecular pathways, such as the regulation of chromatin state, gene expression, and DNA damage …

The ATRX status is one of the critical markers that define the molecular classification of gliomas. In this review, we will first provide an overview of the role of ATRX in regular cell biology. Furthermore, the role of ATRX in tumorigenesis, specifically gliomas, is …

Jun 23, 2021 · Occurs in pediatric and adult high grade astrocytoma (Mod Pathol 2013;26:1425) Alternative Lengthening of Telomeres (ALT) is a non-telomerase mechanism of telomere lengthening that occurs in ~10% of cancers overall and is particularly common in astrocytic brain tumors; ATRX may be a repressor of ALT (PLoS One 2012;7:e50062, Oncotarget 2012;3:1194)

ATRX is one of the most frequently mutated tumor suppressor genes in human cancers. ATRX protein is a chromatin remodeler and transcriptional regulator that is essential for normal development. ATRX plays a crucial role in several essential cellular ...

Jun 23, 2021 · ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA structures.

Mar 7, 2023 · ATRX is a central player regulating the DNA damage response and prevents chromosomal instability. ATRX limits the formation of secondary structures that can trigger replication fork stalling and replication stress. Furthermore, ATRX regulates DNA repair via homologous recombination.