Sep 10, 2020 · Atherosclerosis is a chronic inflammatory disease in which there is a build up of plaques inside arteries. These plaques are principally composed of lipids that induce an inflammatory reaction causing turbulent flow with atherosclerotic cardiovascular disease (ASCVD) as …

Sep 27, 2024 · Hyperlipidemia can significantly increase a person's risk of developing cardiovascular disease, including disease of blood vessels supplying the heart (coronary artery disease), brain (cerebrovascular disease), and limbs (peripheral artery disease).

Therefore, this review deals with the lipid involvement characterizing the pathophysiology of atherosclerosis, discussing some recently proposed non-traditional lipid indices and, in the light of available knowledge, their actual potential as new additive tools to better stratify cardiovascular risk in patients with hyperlipidemia as well as pos...

Nov 19, 2024 · Combination therapy with low-density lipoprotein cholesterol (LDL-C)–lowering therapies with proven outcome benefit is increasingly needed for patients with peripheral artery disease (PAD) to achieve lower LDL-C levels that meet current guideline recommendations.

Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways that control the inflammation. This article reviews the role of ...

Oct 14, 2020 · This article will focus on the role of lipids in the development of atherosclerosis and summarise currently recommended targets for lipid-lowering treatment as a means of reducing cardiovascular risk.

In this review, we describe the cumulative effect of lipid carrying lipoproteins on the risk of cardiovascular disease, estimate the magnitude of the potential clinical benefit that can be achieved by maintaining optimal lipid levels, identify the most effective timing for implementing strategies designed to achieve and maintain optimal lipid le...

May 29, 2019 · Observational studies using trajectory methodology provide new and important insights into our understanding of true prevention of ASCVD, beyond recapitulating the obvious, high LDL cholesterol is bad for you.

Jan 3, 2019 · Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for the pathogenesis of atherosclerosis.

Mar 13, 2025 · Background High LDL-cholesterol (LDL-C) is a well-known risk factor for coronary artery disease (CAD). PCSK9, HMGCR, NPC1L1, ACLY, and LDLR gene have been reported as lipid lowering drug genes related to LDL-C lowering. However relevant Asian studies were rare. Methods We examined the causality between LDL-c drug target genes and CAD using Korean and Japanese data using the two sample ...