Bioengineered with living cells to transform wounds from chronic to acute, Apligraf is a skin substitute that's backed by extensive, reliable, and unmatched evidence in both VLUs and DFUs. 1-8 DFU=diabetic foot ulcer; VLU=venous leg ulcer

Learn how Apligraf® helps your patients with venous leg ulcers and diabetic foot ulcers to heal.

Examine the clinical and real-world evidence for Apligraf, or contact an Organogenesis Tissue Regeneration Specialist today to get more information about how Apligraf can help your VLU and DFU patients.

Apligraf® is indicated for use with standard therapeutic compression for the treatment of non-infected partial- and full-thickness skin ulcers due to venous insufficiency of greater than one month duration and which have not adequately responded to conventional ulcer therapy.

Apligraf has been used to treat many thousands of patients. When combined with compression therapy, Apligraf has been shown to heal more venous leg ulcers than standard therapy alone.

Feb 1, 1993 · Apligraf® (Organogenesis, Canton, MA) is a bi-layered bioengineered skin substitute and was the first engineered skin US Food and Drug Administration (FDA)-approved to promote the healing of ulcers that have failed standard wound care.

• Apligraf is the ONLY product FDA-approved to heal venous leg ulcers (VLUs) after 4 weeks of failed conventional therapy 3 • Apligraf is also FDA-approved to heal diabetic foot ulcers (DFUs) after 3 weeks of failed conventional

Apligraf is an FDA-approved dressing used for chronic venous ulcers. It is a bilayered skin made up of keratinocytes and exposed to oxygen during manufacturing. During heading, it mimics the epidermis and dermis of natural skin.

Apligraf is a living, cell-based, bilayered skin substitute. INTENDED USE: For treating chronic venous leg ulcers and diabetic foot ulcers. CLAIMED FEATURES: The lower layer contains bovine type 1 collagen and human fibroblasts to form a dermis-like structure that produces additional matrix proteins.

Apligraf is a skin substitute bioengineered with living cells 1-4 that helps transform wounds from chronic to acute and heal VLUs and DFUs faster. 5-11 Apligraf overview Examine how Apligraf can help heal stalled wounds by looking, functioning, and responding like healthy skin. 1-4